Lassa virus (LASV) is endemic to West Africa, where it is responsible for causing a potentially severe hemorrhagic fever in humans... The proposed research seeks to address the urgent need for effective control strategies against LASV in West Africa by evaluating the potential impact of a transmissible vaccine...Â
Coexistence in ecology is the ability of species to live together over time without one outcompeting the other. Key concepts include niche differentiation, where species use different resources, and stabilizing mechanisms that increase the negative effects of intra-specific competition over inter-specific competition. For immunology and vaccine development, the coexistence of different viral strains is crucial. It ensures broader immune protection, prevents escape mutants, and addresses strain displacement or superinfection risks... Read more